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2. 90 degree Inclined Pulsar
- Abstract:
- Current sheet and open field lines with footpoints near the edge of the polar cap. The magnetic axis is inclined relative to the rotation axis by 90 degrees. Red field lines originate on the north polar cap and green field lines in the right panel originate on the south polar cap. Purple and grey colors indicate positive and negative net local charge density in the current sheet, which is shown between 1.2-2 light cylinder radii.
- Type:
- moving image
- Issue Date:
- 21 November 2013
3. A dual-mechanism antibiotic kills Gram-negative bacteria and avoids drug resistance
- Author(s):
- Martin, James K; Sheehan, Joseph P; Bratton, Benjamin P; Moore, Gabriel M; Mateus, André; Li, Sophia Hsin-Jung; Kim, Hahn; Rabinowitz, Joshua D; Typas, Athanasios; Savitski, Mikhail M; Wilson, Maxwell Z; Gitai, Zemer
- Abstract:
- The rise of antibiotic resistance and declining discovery of new antibiotics have created a global health crisis. Of particular concern, no new antibiotic classes have been approved for treating Gram-negative pathogens in decades. Here, we characterize a compound, SCH-79797, that kills both Gram-negative and Gram-positive bacteria through a unique dual-targeting mechanism of action (MoA) with undetectably-low resistance frequencies. To characterize its MoA, we combined quantitative imaging, proteomic, genetic, metabolomic, and cell-based assays. This pipeline demonstrates that SCH-79797 has two independent cellular targets, folate metabolism and bacterial membrane integrity, and outperforms combination treatments in killing MRSA persisters. Building on the molecular core of SCH-79797, we developed a derivative, Irresistin-16, with increased potency and showed its efficacy against Neisseria gonorrheae in a mouse vaginal infection model. This promising antibiotic lead suggests that combining multiple MoAs onto a single chemical scaffold may be an underappreciated approach to targeting challenging bacterial pathogens.
- Type:
- Dataset
- Issue Date:
- 20 May 2020
4. Accessing Real-Life Episodic Information from Minutes versus Hours Earlier Modulates Hippocampal and High-Order Cortical Dynamics
- Author(s):
- Chen, Janice; Honey, Christopher; Simony, Erez; Arcaro, Michael; Norman, Kenneth; Hasson, Uri
- Abstract:
- It is well known that formation of new episodic memories depends on hippocampus, but in real-life settings (e.g., conversation), hippocampal amnesics can utilize information from several minutes earlier. What neural systems outside hippocampus might support this minutes-long retention? In this study, subjects viewed an audiovisual movie continuously for 25 min; another group viewed the movie in 2 parts separated by a 1-day delay. Understanding Part 2 depended on retrieving information from Part 1, and thus hippocampus was required in the day-delay condition. But is hippocampus equally recruited to access the same information from minutes earlier? We show that accessing memories from a few minutes prior elicited less interaction between hippocampus and default mode network (DMN) cortical regions than accessing day-old memories of identical events, suggesting that recent information was available with less reliance on hippocampal retrieval. Moreover, the 2 groups evinced reliable but distinct DMN activity timecourses, reflecting differences in information carried in these regions when Part 1 was recent versus distant. The timecourses converged after 4 min, suggesting a time frame over which the continuous-viewing group may have relied less on hippocampal retrieval. We propose that cortical default mode regions can intrinsically retain real-life episodic information for several minutes.
- Type:
- Dataset
- Issue Date:
- 3 August 2015
5. Achromonodin-1 NMR spectra
- Author(s):
- Link, A. James; Carson, Drew V.; So, Larry; Cheung-Lee, Wai Ling
- Abstract:
- This entry encompasses the raw NMR spectra used to determine the structure of the lasso peptide achromonodin-1. Within one file are included the five following spectra: COSY, TOCSY, NOESY (150 ms mixing time), NOESY (700 ms mixing time), and C,H HSQC. The file requires Mestrenova software to read. These spectra were used to develop the 3D structure models of achromonodin-1 that are deposited at the protein data bank (PDB) as entry 8SVB.
- Type:
- Dataset
- Issue Date:
- June 2023
6. Aligned Nonspinning Dipoles
- Abstract:
- Magnetic field lines and current sheets for an orbiting neutron star binary with the magnetic moments of both stars aligned with the rotation axis. The stars are not spinning, i.e., R_{LC,∗} = ∞. Fields are by and large confined to the half of the magnetosphere closer to their source star. This movie shows the corotating field pattern as the orbit progresses.
- Type:
- moving image
- Issue Date:
- 21 November 2013
7. Aligned Rapidly Spinning Dipoles
- Abstract:
- Magnetic field lines and current sheets for an orbiting neutron star binary with the magnetic moments of both stars aligned with the rotation axis. The stars are spinning rapidly at ∼ ms periods, with R_{LC,∗}/R_∗ = 2.7. Stellar spin winds fields backwards toroidally, and they can propagate to the far side of the magnetosphere closer to the opposing star. This movie shows the corotating field pattern as the orbit progresses.
- Type:
- moving image
- Issue Date:
- 21 November 2013
8. Amplification of local changes along the timescale processing hierarchy
- Author(s):
- Yeshurun, Yaara; Nguyen, Mai; Hasson, Uri
- Abstract:
- Small changes in word choice can lead to dramatically different interpretations of narratives. How does the brain accumulate and integrate such local changes to construct unique neural representations for different stories? In this study we created two distinct narratives by changing only a few words in each sentence (e.g. “he” to “she” or “sobbing” to “laughing”) while preserving the grammatical structure across stories. We then measured changes in neural responses between the two stories. We found that the differences in neural responses between the two stories gradually increased along the hierarchy of processing timescales. For areas with short integration windows, such as early auditory cortex, the differences in neural responses between the two stories were relatively small. In contrast, in areas with the longest integration windows at the top of the hierarchy, such as the precuneus, temporal parietal junction, and medial frontal cortices, there were large differences in neural responses between stories. Furthermore, this gradual increase in neural difference between the stories was highly correlated with an area’s ability to integrate information over time. Amplification of neural differences did not occur when changes in words did not alter the interpretation of the story (e.g. “sobbing” to “crying”). Our results demonstrate how subtle differences in words are gradually accumulated and amplified along the cortical hierarchy as the brain constructs a narrative over time.
- Type:
- Dataset
- Issue Date:
- August 2017
9. An extended MHD study of the 16 October 2015 MMS diffusion region crossing
- Abstract:
- The Magnetospheric Multiscale (MMS) mission has given us unprecedented access to high cadence particle and field data of magnetic reconnection at Earth's magnetopause. MMS first passed very near an X-line on 16 October 2015, the Burch event, and has since observed multiple X-line crossings. Subsequent 3D particle-in-cell (PIC) modeling efforts of and comparison with the Burch event have revealed a host of novel physical insights concerning magnetic reconnection, turbulence induced particle mixing, and secondary instabilities. In this study, we employ the Gkeyll simulation framework to study the Burch event with different classes of extended, multi-fluid magnetohydrodynamics (MHD), including models that incorporate important kinetic effects, such as the electron pressure tensor, with physics-based closure relations designed to capture linear Landau damping. Such fluid modeling approaches are able to capture different levels of kinetic physics in global simulations and are generally less costly than fully kinetic PIC. We focus on the additional physics one can capture with increasing levels of fluid closure refinement via comparison with MMS data and existing PIC simulations. In particular, we find that the ten-moment model well captures the agyrotropic structure of the pressure tensor in the vicinity of the X-line and the magnitude of anisotropic electron heating observed in MMS and PIC simulations. However, the ten-moment model has difficulty resolving the lower hybrid drift instability, which has been observed to plays a fundamental role in heating and mixing electrons in the current layer.
- Type:
- Dataset
10. Antialigned Nonspinning Dipoles
- Abstract:
- Magnetic field lines and current sheets for an orbiting neutron star binary with the magnetic moment of one star aligned with the rotation axis, and the magnetic moment of the other star tilted and antialigned with the rotation axis. The stars are not spinning, i.e., R_{LC,∗} = ∞. Fields from each star encircle the other star and force fields coming off the second star backwards toroidally. This movie shows the corotating field pattern as the orbit progresses.
- Type:
- moving image
- Issue Date:
- 21 November 2013
