Wang, Rui; Guo, Xuehui; Pan, Da; Kelly, James; Bash, Jesse; Sun, Kang; Paulot, Fabien; Clarisse, Lieven; Van Damme, Martin; Whitburn, Simon; Coheur, Pierre-François; Clerbaux, Cathy; Zondlo, Mark
Monthly, high resolution (~2 km) ammonia (NH3) column maps from the Infrared Atmospheric Sounding Interferometer (IASI) were developed across the contiguous United States and adjacent areas. Ammonia hotspots (95th percentile of the column distribution) were highly localized with a characteristic length scale of 12 km and median area of 152 km2. Five seasonality classes were identified with k-means++ clustering. The Midwest and eastern United States had a broad, spring maximum of NH3 (67% of hotspots in this cluster). The western United States, in contrast, showed a narrower mid-summer peak (32% of hotspots). IASI spatiotemporal clustering was consistent with those from the Ammonia Monitoring Network. CMAQ and GFDL-AM3 modeled NH3 columns have some success replicating the seasonal patterns but did not capture the regional differences. The high spatial-resolution monthly NH3 maps serve as a constraint for model simulations and as a guide for the placement of future, ground-based network sites.
Kinetic modification of ideal stability theory from stabilizing resonances of mode-particle interaction has had success in explaining resistive wall mode (RWM) stability limits in tokamaks. With the goal of real-time stability forecasting, a reduced kinetic stability model has been implemented in the new Disruption Event Characterization and Forecasting (DECAF) code, which has been written to analyze disruptions in tokamaks. The reduced model incorporates parameterized models for ideal limits on beta, a ratio of plasma pressure to magnetic pressure, which are shown to be in good agreement with DCON code calculations. Increased beta between these ideal limits causes a shift in the unstable region of delta W_K space, where delta W_K is the change in potential energy due to kinetic effects that is solved for by the reduced model, such that it is possible for plasmas to be unstable at intermediate beta but stable at higher beta. Gaussian functions for delta W_K are defined as functions of E cross B frequency and collisionality, with parameters reflecting the experience of the National Spherical Torus Experiment (NSTX). The reduced model was tested on a database of discharges from NSTX and experimentally stable and unstable discharges were separated noticeably on a stability map in E cross B frequency, collisionality space. The reduced model only failed to predict an unstable RWM in 15.6% of cases with an experimentally unstable RWM and performed well on predicting stability for experimentally stable discharges as well.
Martin, James K; Sheehan, Joseph P; Bratton, Benjamin P; Moore, Gabriel M; Mateus, André; Li, Sophia Hsin-Jung; Kim, Hahn; Rabinowitz, Joshua D; Typas, Athanasios; Savitski, Mikhail M; Wilson, Maxwell Z; Gitai, Zemer
The rise of antibiotic resistance and declining discovery of new antibiotics have created a global health crisis. Of particular concern, no new antibiotic classes have been approved for treating Gram-negative pathogens in decades. Here, we characterize a compound, SCH-79797, that kills both Gram-negative and Gram-positive bacteria through a unique dual-targeting mechanism of action (MoA) with undetectably-low resistance frequencies. To characterize its MoA, we combined quantitative imaging, proteomic, genetic, metabolomic, and cell-based assays. This pipeline demonstrates that SCH-79797 has two independent cellular targets, folate metabolism and bacterial membrane integrity, and outperforms combination treatments in killing MRSA persisters. Building on the molecular core of SCH-79797, we developed a derivative, Irresistin-16, with increased potency and showed its efficacy against Neisseria gonorrheae in a mouse vaginal infection model. This promising antibiotic lead suggests that combining multiple MoAs onto a single chemical scaffold may be an underappreciated approach to targeting challenging bacterial pathogens.
F. M. Laggner, A. Diallo, B. P. LeBlanc, R. Rozenblat, G. Tchilinguirian, E.Kolemen, the NSTX-U team
A detailed description of a prototype setup for real-time (rt) Thomson scattering (TS) analysis is presented and implemented in the multi-point Thomson scattering (MPTS) diagnostic system at the National Spherical Torus Experiment Upgrade(NSTX-U). The data acquisition hardware was upgraded with rt capable electronics (rt-analog digital converters (ADCs) and a rt server) that allow for fast digitization of the laser pulse signal of eight radial MPTS channels. In addition, a new TS spectrum analysis software for a rapid calculation of electron temperature (Te) and electron density (ne) was developed. Testing of the rt hardware and data analysis soft-ware was successfully completed and benchmarked against the standard, post-shot evaluation. Timing tests were performed showing that the end-to-end processing time was reproducibly below 17 ms for the duration of at least 5 s, meeting a 60 Hz deadline by the laser pulse repetition rate over the length of a NSTX-U discharge. The presented rt framework is designed to be scalable in system size, i.e. incorporation of additional radial channels by solely adding additional rt capable hardware. Furthermore, it is scalable in its operation duration and was continuously run for up to 30 min, making it an attractive solution for machines with long discharge duration such as advanced, non-inductive tokamaks or stellarators.